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KMID : 0608520010070010115
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Korean Journal of Oriental Medicine
2001 Volume.7 No. 1 p.115 ~ p.124
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Effects of Yukmijihwangwon on Hypoxia of Ncuronal Cells
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강봉주
홍성길/조동욱
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Abstract
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Yukmijinhwangwon(YM) has been known to reinforce the vital essence and have antioxidant activities. This study was designed to examine the inhibitory effects of YM against in vitro hypoxia/reperfusion-induced inflammatory response. We have characterized the production of prostaglandin E₂and arachidonic acid during hypoxia/reperfusion in the human neuroblastoma SK-N-MC and human monocytic macrophage U937 cells and the ingibitory effect of YM on these inflammation-related substance formation has been found out in this study. To investigate inhibition of COX expression by YM during hypoxia in vitro. This result suggested that YM used in this experiment reinforced antiinflammatory potentials and protected cells against hypoxia/reperfusion induced inflammatory response.
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KEYWORD
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Yukmijihwangwon , antiinflammation , COX-2 , prostaglandin E_2
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